Drug Discovery and Development

HDAC Inhibitor Drug Discovery - Design of Histone Deacetylase Inhibitors as Potential anti-cancer agents

Histone Deacetylase (HDAC) inhibitors represent a budding class of targeted anti-cancer agents. This structurally diverse group of molecules can induce growth arrest, differentiation, apoptosis, and autophagocytic cell death of cancer cells. More...

Taxane Drug Discovery

Screening of effective natural taxanes has been actively pursued with the aim of identifying natural taxanes with potent β tubulin inhibition and multidrug resistance (MDR) modulation. Seventy two natural β tubulin inhibitors have been segregated from two hundred and sixty natural taxanes available at Taxane Knowledge Base (Tax KB). More...

Development of novel drug for the prevention of End-stage Renal Disease (ESRD)

Kidney failure or renal failure is a condition wherein the kidneys are unable to perform their basic functions adequately and the metabolic wastes and toxins such as Urea, Creatinine, Uric-acid, Ammonia, Creatine etc. starts accumulating in the serum and are abnormally elevated in our body. Physiologically, renal failure could be seen as a rapid decrease in the Glomerular Filtration Rate (GFR). More...