Nitric Oxide


Liver Angiogenesis

Endothelium in Extreme Environment




Thalidomide targets sGC..

Ultralow cadmium inactivates eNOS.....

Ang001 antagonizes angiogenesis.....

Microgravity promotes angiogenesis.

The European Union (EU) and Marie Curie Program [more...]

Nature Publishing Group travel award 2010

Best Poster Award at Cancercon 2010

Best Poster Award at SFRR 2010

Awarded Visiting student fellowship by UWA, Perth - 2009

Selected for Presentation at GORDON Conference-Thiol mediated stress response and signaling- 2008

Selected for Presentation at EURO CONFERENCE ON APOPTOSIS -2008

Awarded BOEHRINGER INGELHEIM FONDS travel fellowship - 2008

Best Investigator Award at SFRR- 2007

Awarded IUBMB WOOD WHELAN Fellowship 2007

Selected for Presentation at GORDON Conference- Nitric Oxide 2007






Nitric oxide, a gaseous signaling molecule, is implicated in various physiological events from vascular smooth muscle relaxation to blood vessel formation, extending to pathophysiology to patholgy, ranging from stroke to cancer.


The core research interest of Vascular Biology Lab is to understand the nitric oxide signaling in endothelium.









Recent Publications and patents…..


  1. Tipping off endothelial tubes: Nitric oxide drives tip cells (2014) M. Krishnapriya M, Sahu G, Pantoja DS, Goldy N, Meenakshi A, Jadhav V, Saran U, B.M. Jaffar Ali, Roberts DD, Bera AK, and Chatterjee S, Angiogenesis. 2014 Dec 16. [Epub ahead of print]
  1. Sinapic acid protects heart against ischemia/reperfusion injury and H9c2 cardiomyoblast cells against oxidative stress (2014) Thangarasu Silambarasan; Jeganathan Manivannan; Mani Krishna Priya; Natarajan Suganya; Chatterjee S, Boobalan Raja. Biochem Biophys Res Commun. 2014 Dec 13. pii: S0006-291X(14)02187-1. doi: 10.1016/j.bbrc.2014.12.022. [Epub ahead of print]
  1. Cadmium induced embryopathy: Nitric Oxide rescues teratogenic effects of Cadmium (2014) Veeriah V, Saran U, Swaminathan A, Balaguru UM, Thangaraj P, Nagarajan S, Rajendran VK, Chatterjee S, Toxicol Sci. 2014 Dec 8. pii: kfu258. [Epub ahead of print].
  1. Sinapic Acid Alleviates Hypertension and Cardiovascular Remodeling in Nitric Oxide Deficient Rats (2014) Silambarasan T, Manivannan J, Krishna Priya M; Suganya N, Chatterjee S, Raja B. PLoS One. 2014 Dec 22;9(12):e115682. doi: 10.1371/journal.pone.0115682. eCollection 2014.
  1. Bioconjugated gold nanoparticles accelerate the growth of new blood vessels through redox signaling (2014) Nethi SK, Mukherjee S, Veeriah V, Barui AK, Chatterjee S, Patra CR. Chem Commun (Camb). 2014 Nov 28;50(92):14367-70.
  1. Rho kinase as a therapeutic target in vascular diseases: Striking nitric oxide-signaling (2014) Kolluru GK, Majumder S, Chatterjee S, Nitric Oxide. 1(43C):45-54.
  1. Role of angiogenesis in bone repair (2014) Saran U, Piperni SG, Chatterjee S, Arch Biochem Biophys 1;561C:109-117.
  1. MiR-29b downregulates canonical Wnt signaling by targeting BCL9L and other coactivators of β-catenin in human colorectal cancer cells (2014) Subramanian M, Rao S.R., Thacker P, Sathyanarayanan A, Chatterjee S and Karunagaran D. J Cell Biochem. 115(11):1974-84.
  1. Evaluation of wound healing and chemotactic activities of Embelin and Vilangin using human dermal fibroblast (in vitro) model (2014) Radhakrishnan N, Majumder S, Chatterjee S, Gnanamani A . J Chem Pharmaceutical Res 5 (11):768-773.
  1. Reversal of vasohibin driven negative feedback loop of VEGF-angiogenesis axis promises a novel anti-fibrotic therapeutic strategy for liver diseases (2014) Chatterjee S. Hepatology (In press).
  1. A comparative study of NONOate based NO donors: Spermine NONOate is the best suited NO donor for angiogenesis (2014) Majumder S, Sinha S, Siamwala JH, Muley A, Reddy H, Kolluru GK, Veeriah V, Nagarajan S, Sridhara SRC, Kuppusamy M, Srinivasan S, Konikkat S, Soundararajan G, Venkataraman S, Saran U,Chatterjee S. Nitric Oxide. 36:76-86.
  1. Everolimus is a potent inhibitor of activated hepatic stellate cell functions in vitro and in vivo while demonstrating anti-angiogenic activities. (2013) Piguet A, Majumder S, Balaguru UM, Manjunathan R, Saran R, Chatterjee S, Dufour JF . Clinical Science. 126(11):775-84.
  1. Characterization of a pro-angiogenic, novel peptide from Russell's viper (Daboia russelii russelii) venom (2013). Mukherjee AK, Chatterjee S, Majumder S, Saikia D, Thakur R, Chatterjee A. Toxicon.77C:26-31.
  1. Calreticulin transacetylase mediated upregulation of thioredoxin by 7,8-diacetoxy-4-methylcoumarin enhances the antioxidant potential and the expression of vascular endothelial growth factor in peripheral blood mononuclear cells. (2013) Joshi R, Kumar A, Manral S, Sinha R, Arora S, Sharma A, Goel S, Kalra N, Chatterji S, Dwarakanath BS, Rawat DS, Depass AL, Rohil V, Saluja D, Parmar VS, Prasad AK, Raj HG. Chem Biol Interact.206 (2):327-336.
  1. Immunomagnetic nanoparticle based quantitative PCR for rapid detection of salmonella (2013) Bakthavathsalam P, Rajendran VK, Saran U, Chatterjee S, and Jaffar ABM. Microchim Acta 180:1241–1248.
  1. Inhibition of Notch signaling induces extensive intussusceptive neo-angiogenesis by recruitment of mononuclear cells (2013) Dimova I, Hlushchuk R, Makanya A, Styp-Rekowska B, Ceausu A, Flueckiger S, Lang S, Semela D, Le Noble F, Chatterjee S, Djonov V. Angiogenesis. 16(4):921-37.
  1. Breast cancer drugs dampen vascular functions by interfering with nitric oxide signaling in endothelium (2013) Gajalakshmi P, Krishna Priya M, Pradeep T, Behera J, Muthumani K, Madhuwanti S, Saran U,Chatterjee S. Toxicology and Applied Pharmacology. 269(2):121-31.
  1. Study of the Cellular Mechanism of Sunitinib Mediated Inactivation of Activated Hepatic Stellate Cells and Its Implications in Angiogenesis (2013) Majumder S, Piguet A, Dufour JF,Chatterjee S. European Journal of Pharmacology. 705(1-3):86-95.
  1. Effect of simulated microgravity on E. coli K12 MG1655 growth and gene expression (2013) Arunasri, K., Mohammed A, Venu Charan, K., Chatterjee S, Himabindu Reddy, S. and Shivaji, S. Plos One PONE-D-12-34870.
  1. Nitric oxide protects endothelium from cadmium mediated leakiness (2013) Nagarajan S, Rajendran S, Saran U, Priya MK, Swaminathan A, Siamwala JH, Sinha S, Veeriah V, Sonar P, Jadhav V, Ali BM, Chatterjee S. Cell Biol Int. (In press).
  1. Engineering chitosan using α , ? - dicarboxylic acids - An approach to improve the mechanical strength and thermal stability (2013) Gnanamani A, Mitra T, Sailakshmi G, Gnanamani A, Chatterjee S. Journal of Biomaterials and Nanobiotechnology (In press).
  1. Zinc oxide nanoflowers make new blood vessels (2012) Barui AK, Veeriah V, Mukherjee S, Manna J, Patel AK, Patra S, Pal K, Murali S, Rana RK, Chatterjee S, Patra CR. Nanoscale. 21:4:7861-9.
  1. Nitrites derived from Foneiculum vulgare (Fennel) seeds promotes vascular functions (2012) Swaminathan A, Sridhara, Swaraj SRA, Sinha S, Nagarajan S, Balaguru UM, Siamwala JH, Rajendran S, Saran U, Chatterjee S. J Food Sci. 77(12):H273-9.
  1. Nitric oxide rescues thalidomide mediated teratogenicity (2012) Jamila H Siamwala, Vimal Veeriah, Krishna Priya M, Saranya Rajendran, Uttara Saran, Swaraj Sinha, Shunmugam Nagarajan, Pradeep T and Chatterjee S. Scientific Reports 2:679.
  1. Suberic Acid Acts as a Dissolving agent as well as a crosslinker for natural polymers (carbohydrate and protein): A detailed discussion on the chemistry behind the interaction (2012) G. Sailakshmi, Mitra T, Sinha S, Chatterjee S, A. Gnanamani and Mandal AB J. Macromol. Sci. Part A – Pure and Applied Chemistry. 49: 8.
  1. TNF α signaling beholds thalidomide saga: A review of mechanistic role of TNF-α signaling under thalidomide (2012) Majumder S, Sreedhara SR, Banerjee S, Chatterjee S. Curr Top Med Chem. 12(13):1456-67.
  1. L-theanine promotes nitric oxide production in endothelial cells through eNOS phosphorylation (2012) Siamwala JH, Paul DM, Majumder S, Joshi M, Sinkar VP, Banerjee G, and Chatterjee S J Nutr Biochem (In Press)
  1. Inhibitory activity of the peptides derived from buffalo prolactin on angiogenesis (2011) Lee J, Majumder S, Chatterjee S, and Muralidhar K. J Biosci. 36:341-54.
  1. Stimulated Microgravity Promoted Differentiation of Bipotential Murine Oval Stem cells by Modulating BMP4/Notch1 Signaling (2011) Symantak Majumder, Jamila H. Siamwala, Sundaramoorthy Srinivasan, Swaraj Sinha, Sree Rama Chaitanya Sridhara, Gowrishankar Soundararajan, Himabindu Reddy Seerapu, and Chatterjee S. J. Cell. Biochem 112:1898-1908.
  1. Elevated glutathione level does not protect against chronic alcohol mediated apoptosis in recombinant human hepatoma cell line VL-17A over-expressing alcohol metabolizing enzymes--alcohol dehydrogenase and Cytochrome P450 2E1.(2011) Chandrasekaran K, Swaminathan K, Kumar SM, Chatterjee S, Clemens DL, Dey A. Toxicol In Vitro. 25:969-78.
  1. Normalization of Deranged Signal Transduction in Lymphocytes of COPD Patients by the Novel Calcium Channel Blocker H-DHPM (2011) Sushma Manrala, Sumati Bhatiab, Rajesh Sinhaa, Ajit Kumara, Vishwajeet Rohila, Anu Aryab, Ashish Dhawanb, Pragya Aryab, Rini Joshia, Sreerama C. Sreedharac, Sukanya Gangopadhyaya, Surendra K. Bansala, Suvro Chatterjee, Nabo K. Chaudhuryd, Ashok K. Prasadb*, Vannan K. Vijayane, Virinder S. Parmarb, Shyam Biswalf, Anthony L. DePassg, Hanumantharao G. Raja*. Bichimie 93:1146-56.
  1. NO (Nitric oxide): The Ring Master (2011) Sinha S, Sridhara SRC, Srinivasan S, Muley A, Majumder S, Kuppusamy M, Gupta R, Chatterjee S Eur J Cell Biol. 90 (1):58-71.
  1. Rajkumar AS, Muley A, Chatterjee S and Jaffar Ali BM (2010) Probing the effect of elevated cholesterol on the mechanical properties of membrane-cytoskeleton by optical tweezers. Proc. of SPIE Vol. 7762 77621K-1.
  1. Simulated microgravity promotes nitric oxide-supported angiogenesis using the iNOS-cGMP-PKG pathway in macrovascular endothelial cells (2010) Siamwala JH, Majumder S, Tamilarasan KP, Muley A, Seerapu HR, Kolluru GK, Sinha S, Chatterjee S. FEBS Letter 584 (15):3415-3423.
  1. Chick embryo partial ischemia model: a new approach to study ischemia ex vivo (2010) Majumder S, Ilayaraja M, Seerapu HR, Sinha S, Siamwala JH, Chatterjee S. PLoS One. 7;5(5):e10524.
  1. Inhibition of dynamin-2 confers endothelial barrier dysfunctions by attenuating nitric oxide production (2010) Seerapu HB, Subramaniam GP, Majumder S, Sinha S, Bisana S, Mahajan S, Kolluru GK, Muley A, Siamwala JH, G I, Chatterjee S. Cell Biol Int. 34(7):755-761.
  1. eNOS phosphorylation in health and disease (2010) Kolluru GK, Siamwala JH, Chatterjee S. Biochimie. 92(9):1186-1198.
  1. Shear stress promotes nitric oxide production in endothelial cells by sub-cellular delocalization of eNOS: A basis for shear stress mediated angiogenesis (2010) Kolluru GK, Sinha S, Majumder S, Muley A, Siamwala JH, Gupta R, Chatterjee S. Nitric Oxide. 22(4):304-315.
  1. Simulated microgravity perturbs actin polymerization to promote nitric oxide associated migration in human immortalized Eahy926 cells (2010) Jamila H Siamwala , Himabindu Reddy.S, Syamantak Majumder, Gopi Krishna Kolluru, Ajit Muley, Swaraj Sinha, Chatterjee S . Protoplasma 242(1-4):3-12.
  1. Calreticulin transacylase: genesis, mechanism of action and biological applications (2010) Kumari R, Bansal S, Gupta G, Arora S, Kumar A, Goel S, Singh P, Ponnan P, Priya N, Tyagi TK, Baghel AS, Manral S, Tandon R, Joshi R, Rohil V, Gaspari M, Kohli E, Tyagi YK, Dwarakanath BS, Saluja D, Chatterji S, Sharma SK, Prasad AK, Rastogi RC, Raj HG, Parmar VS. Biochimie. 92(9):1173-9.
  1. Evaluation of the role of Nitric Oxide in acid sensing ion channel mediated cell death (2010) Jetti SK, Swain SM, Majumder S, Chatterjee S, Venkateshamurthy P, Bera A Nitric Oxide 22(3):213-9.
  1. Secreted Frizzled-Related Protein 4: An Angiogenesis Inhibitor (2010) Muley A, Majumder S, Kolluru GK, Parkinson S, Viola H, Hool L, Arfuso F, Ganss R, Dharmarajan A , Chatterjee S Am J Pathol. 176(3):1505-16.
  1. Apoptosis in HepG2 cells exposed to high glucose (2010) Chandrasekaran K, Swaminathan K, Chatterjee S, Dey A (2010). Toxicology In Vitro 24(2):387-96.
  1. Molecular Pathogenesis and Drug Targets in Cardiac Myxoma (2009) Barh D, Kumar A, Chatterjee S, and Liloglou T Curr Cancer Drug Targets. 9(6):705-16.
  1. Thalidomide attenuates nitric oxide driven angiogenesis by interacting with soluble guanylate cyclase (2009) Majumder S, Rajaram M, Muley A, Himabindu Reddy S, Tamilarasan KP, Kolluru GK, Sinha S, Siamwala JH, Gupta R, Ilavarasan R, Venkataraman S, Sivakumar KC, Anishetty S, Pradeep Kumar G, Chatterjee S. Br J Pharmacol. 158(7); 1720-1734.
  1. Antiangiogenic Activity of Buffalo Growth Hormone (2009) Majumder S, Chatterjee S, Lee JO and Muralidhar K.. Science and Culture, Vol. 76 (Sep-Oct), 2009.
  1. Cadmium attenuates bradykinin driven nitric oxide production by interplaying with the localization pattern of endothelial nitric oxide synthase (2009) Majumder S, Gupta R, Himabindu Reddy S., Sinha S, Muley A, Kolluru GK, Chatterjee S. Biochem Cell Biol. 87(4):605-20.
  1. The Role of Calreticulin Transacetylase in the Activation of Human Platelet Nitrite Reductase by Polyphenolic Acetates (2009) Arora S, Tyagi YK, Kumar A, Majumder S, Saluja D, Raj HG, Chatterjee S, Saso L, Prasad AK, Singh PV Biological and Pharmaceutical Bulletin. 32(2):161-5.
  1. Nitric oxide-cGMP shields the endothelial cells from hypoxia-mediated leakiness (2008) Kolluru GK, Tamilarasan KP, Rajkumar AS, Geetha Priya S, Rajaram M, Saleem NK, Majumder S, Jaffar Ali BM, Illavazagan G, Chatterjee S. Eur. J. Cell Biol. 87:147-61.
  1. Cadmium reduces nitric oxide production by impairing phosphorylation of endothelial nitric oxide synthase (2007) Majumder S, Muley A, Kolluru GK, Saurabh S, Tamilarasan KP, Chandrasekhar S, Reddy H, Purohit SB, Chatterjee S Biochem Cell Biol 85:709-720.
  1. Activated pericyte attenuates endothelial functions: Nitric oxide cGMP rescues activated pericyte associated endothelial dysfunctions (2007) Majumder S, Tamilarasan KP, Kolluru GK, Muley A, Nair C M, Omanakuttan A, Murty KVGK and Chatterjee S. Bicohem Cell Biol. 85 (6):709-20.
  1. Characterization of the CXCR4 Signaling in Pancreatic Cancer Cells (2007) Billadeau DD, Chatterjee S, Bramati P, Sreekumar R, Shah V, Hedin K and Urrutia R. Int J Gastrointest Canc 37: 110-9.
  1. Nitric oxide promotes endothelial cell survival signaling through S-nitrosylation and activation of dynamin-2 (2007) Kang-Decker N, Cao S, Chatterjee S, Yao J, Egan LJ, Semela D, Mukhopadhyay D, Shah V J Cell Sci 120:492-501.
  1. Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking (2006) Iwakiri Y, Satoh A, Chatterjee S, Toomre DK, Chalouni CM, Fulton D, Groszmann RJ, Shah VH, Sessa WC Proc Natl Acad Sci U S A. Dec 26;103(52):19777-82.
  1. Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells (2006) Tamilarasan KP, Kolluru GP, Rajaram M, Indhumathy M, Saranya R, Chatterjee S (2006). BMC Cell Biol. 4;7:17.
  1. Cadmium induced endothelial dysfunctions: Consequence of defective migratory pattern of endothelial cells in association with poor nitric oxide availability under cadmium challenge (2006) Kolluru GK, Tamilarasan KP, Geeetha Priya S, Durgha NP, Chattergee S Cell Biol. Int. 30(5): 427-38.

Book Chapters

  1. Developing an ex vivo Model of ischemia using early Chick-embryo: a model to study ischemia related angiogenesis. NIH Hand book of Angiogenesis Protocol (2012) Syamantak Majumder, Sree Rama Chaitanya Sridhara and Suvro Chatterjee. The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications 2012, pp 241-251.
  1. Hypoxia Induces Endothelial Barrier Dysfunctions in Lungs: Nitric Oxide Perturbs Actin Dynamics in Endothelial Cells”. Swaraj Sinha, Hima Bindu Reddy, Suvro Chatterjee. Actin: Structure, Functions and Disease. Nova publishers, ISBN: 978-1-62100-191-1.
  1. A nascent angiogenesis model for studying pharmacological nitric oxide donors. Translational Research in New Drug Development (2012) Shree Rama Chaitanya Sridhara, Vivek Jadhav, Swaraj Sinha and Suvro Chatterjee (In Press).


  1. Awarded an International Patent by claiming anti-angiogenesis potential of sFRP4 with Prof. A. Dharmarajan, University of Western Australia (April 2007).

  2. Title: Anti-angiogenic agents and methods of their use
    Publication: WO/2007/115376
    International: PCT/AU2007/000477
    International Filing: 11.04.2007
    Date: 18.10.2007
    Inventors : Suvro Chatterjee (Anna University)
                 Arunasalam Dharmarajan (University of Western Australia)
  1. Filed an Indian Patent by claiming anti-angiogenesis effect of pthalimide analogs.
  2. Title: N- substituted phthalimide derivatives as potential angiogenesis inhibitors
    Publication: 0051NF2011/IN
    National Filing: 05.08.2011
    Date: 18.10.2007
    Inventors : Bikram Singh (IHBT)
         Suvro Chatterjee (Anna University)
         Arunasalam Dharmarajan (University of Western Australia)
         Neeraj Kumar (IHBT)
         Upendra Sharma (IHBT)

For further discussions, collaborations and comments contact

Dr.Suvro Chatterjee
Research Scientist
AU-KBC Research Centre
Anna University, INDIA
Ph: +91-44-22234885
Fax: +91-44-2222711