The Bioinformatics Group at AU-KBC Research Centre is focusing on developing cutting edge technologies in Bioinformatics. Currently we are involving in Drug Discovery and Development, Augmentation of Biotech Products, Tools and Database Development and Training activities.
Drug Discovery and Development
To develop a new drug conventionally, one has to spend one Billion dollar and 10 –12 years time. There is no guarantee of success in this method, in spite of spending so much time and money. New methods for drug discovery are receiving considerable attention in the pharmaceutical industry. Trial-and-error discovery methods have been replaced by focused combinatorial chemistry, computer-aided drug design, and other processes. Genomics and Proteomics are complementary technologies of biological research. Biomarker discovery provides valuable information that can accelerate drug development and improve modern medicine. Integrating all ‘omics’ with modeling and simulation in terms of systems Biology approach will help us to cut short the time and money spent on discovery process. We are concentrating on HDAC inhibitors and Taxanes drug discovery for Cancer. Also focusing on TB and prevention of Chronic End-stage Renal Failure in children with congenital anomalies.
Augmentation of Biotech Products
Through biotechnological process we are obtaining so many useful products.Our approach will focus on a thorough study of the organisms in terms of their genomics, proteomics and metabolomics and integrated with Systems Biology will help us to enhance the productivity of products like Hydrogen, Lovastatin etc. It may be noted that, for many metabolite producers, the entire sequence as well as other information (such as pathways) are available. Using this information an attempt will be made to get thermodynamically efficient metabolite production system for a targeted product.Currently we are focusing on Hydrogen, Lovastatin , Electricity and Biodiesel productivity improvement as case studies.
Tools and Database Development
We have developed various Tools and Databases meant for Life Science research. Also involving in FOSS Bioinfotracker and AIM Blast activities in terms of tool development and providing training.
Kasi Murugan,Shanmugasamy Sangeetha, Saleh Al-Sohaibani1 and Gopal Ramesh kumar (2015) In silico and in vitro screening of flavonoids for HDAC1 and HDAC3 inhibitory activity: Potential epigenetic therapeutic leads for breast cancer. Journal of Molecular Graphics and Modelling (Accepted).
Murugan K, Sangeetha S, Ranjitha S, Vimala A, Al-Sohaibani SA, Rameshkumar G (2015) HDACiDB: A Database for Histone Deacetylase Inhibitors. Drug Design, Development and Therapy (Accepted).
Soumitra Mohanty, Lakshmanan Jagannathan, Geetanjali Ganguli,Avinash Padhi, Debasish Roy, Nader Alaridah, Pratip Saha Upendra Nongthomba, Gabriela Godaly, Gopal Ramesh Kumar , Sulagna Banerjee, and Avinash Sonawane (2015) A mycobacterial phosphoribosyltransferase promotes bacillary survival by inhibiting oxidative stress and autophagy pathways in macrophages and zebrafish. Journal of Biological Chemistry.DOI: 10.1074/jbc.M114.598482
Nupoor Chowdhary, Ashok Selvaraj, Lakshmi KrishnaKumaar, Gopal Ramesh Kumar (2015) Genome wide Re-annotation of Caldicellusiruptor saccharolyticus with New Insights into Genes involved in Biomass Degradation and Hydrogen Production. PLOS ONE (Accepted).
Sathya.B,Akila Parvathy Dharshini, G Ramesh Kumar (2015) NGS Meta Data Analysis for Identification of SNPs and INDELs Pattern in Human Airway Transcriptome: A Preliminary Indicator for Lung Cancer. Applied and Translational Genomics. 4:4–9.